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. 2020 Feb 5;19(5):774–792. doi: 10.1074/mcp.RA119.001860

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© 2020 Martin et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Fig. 4. — Enrichment in AITD patients of IgG N-glycan traits associated with IKZF1 and FUT8 genes. Correlation network between 75 IgG N-glycan traits, highlighting 17 IgG N-glycan traits associated with AITD and TPOAb level and those associated with SNPs close to HLA, FUT8, IKZF1 genes. Nodes represent different IgG N-glycan traits (the color of nodes is related to the associations performed in discovery and replicated cohorts) and connections show the Pearson correlation between IgG N-glycan traits (only correlations more than 0.75 are visualized, red for negative correlation and blue for positive correlation, the strength of correlation is represented by the width of edge). The three clouds above of nodes cluster the different IgG N-glycan traits previously found to be associated with SNPs within/close to HLA gene (blue cloud), the FUT8 gene (yellow cloud) and IKZF1 gene (red cloud (23). Image created with R package qgraph.