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AIG1 and ADTRP regulate nonesterified FAHFA levels in vivo in a tissue-specific manner. Nonesterified 9- and 12/13-PAHSA and OAHSA measurements in (A) BAT, (B) SQWAT, (C) PGWAT, (D) kidney, (E) liver, and (F) plasma of Aig1-KO, Adtrp-KO, and DKO mice relative to the corresponding WT controls. Error bars represent S.D. (n = 4 per group. *, p < 0.05; **, p < 0.01; ***, p < 0.001, compared with WT. t test; #, p < 0.05; DKO compared with Adtrp-KO, t test).
