Table 3.
Kinetic data of top 12 HDCR3 affinity-matured anti-ROR2 clones
| Clone Name | HCDR3 Seq. | KD (nM) | kon (104 m−1 s−1) | koff (10−3s−1) | χ2 |
|---|---|---|---|---|---|
| X3.12 | DDRWSLNI | 0.72 | 4.5 | 0.033 | 0.24 |
| X3.13 | DKGWSLNI | 1.1 | 2.6 | 0.027 | 0.095 |
| X2.12 | DTMSLNI | 1.2 | 3.4 | 0.040 | 0.41 |
| X4.3 | DWGNWSLNI | 1.3 | 3.0 | 0.038 | 0.47 |
| X2.23 | DYTSLNI | 1.4 | 3.3 | 0.047 | 0.36 |
| X2.7 | DSMSLNI | 1.5 | 6.9 | 0.10 | 0.47 |
| X3.21 | DGLTSLNI | 1.9 | 4.9 | 0.092 | 0.33 |
| X4.12 | DYMMNSLNI | 2.8 | 5.3 | 0.15 | 0.31 |
| X3.6 | DSRNSLNI | 3.2 | 6.0 | 0.19 | 0.53 |
| X4.21 | DSGVVSLNI | 3.4 | 2.4 | 0.081 | 0.12 |
| 401 | DWTSLNI | 7.0 | 3.1 | 0.22 | 0.43 |
| X4.9 | DNGSTSLNI | 10 | 3.3 | 0.34 | 0.22 |
| X4.35 | DSRRKSLNI | 31 | 5.4 | 1.7 | 1.5 |