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NLPR3 reversed the inhibitory effect of ANI on the development of HCC xenografts in mice. The mice were randomly divided into four groups (n = 5): Control group, ANI-200 group, ANI-200+pcDNA-NLRP3 group and ANI-200+EV group. (A) The volume of tumors. (B) Survival curve. (C–F) The levels of TG, TC, HDL and LDL. (G) Pathological damage of the liver is detected by H&E staining. (*p < 0.05 vs control group, #p < 0.05 vs ANI-200 group, &p < 0.05 vs ANI-200+pcDNA-NLRP3 group).
