Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Apr 29;13:3583–3594. doi: 10.2147/OTT.S237306

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Lin et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

BCAT1 regulates cyclin D1, MMP7, c-Myc through Wnt signaling. (A) Pearson’s correlation analysis showed positive associations between BCAT1 and cyclin D1, MMP7, c-Myc and TCF4 mRNA in 515 cases of lung cancer. (B) Wnt inhibitor ICG-001 was used in cells transfected with BCAT1 plasmid or control vector. ICG-001 decreased cyclin D1, MMP7, c-Myc protein expression. In cells treated with ICG-001, the effect of BCAT1 on cyclin D1, MMP7 and c-Myc protein was significantly ameliorated. Top-Flash Luciferase reporter assay showed that ICG-001 decreased Wnt signaling activity in BEAS-2B and H1299 cell lines.