Fig. 4.

Inactivation of multiple signaling pathways including the anti-inflammatory pathway under winter-like conditions. (A) Canonical signaling pathways significantly inactivated under winter-like conditions. The x axis shows the inverse logarithm of the Fisher’s exact P value corrected for multiple comparisons using the Benjamini–Hochberg test. The orange line indicates the threshold of significance (P < 0.05). (B) Inactivation of the NRF2-mediated antioxidant response under winter-like conditions. Genes highlighted in magenta and green are summer-induced and summer-repressed genes, respectively.