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. 2020 Apr 10;117(17):9594–9603. doi: 10.1073/pnas.2000278117

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Copyright © 2020 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 6. — Conservation of the HB pathway and possible mechanisms that cause winter behavior. (A) Hypothetical model of the underlying mechanisms regulating seasonal changes in behaviors. (B) Conservation of HB pathways in mammals and fish. Schematic of sagittal sections of rodent and fish brains. Red shows medial (mammal) and dorsal (fish) HB circuitries, while blue shows lateral (mammal) and ventral (fish) HB circuitries. Green shows feedback projections to the hippocampus and medial prefrontal cortex. Although the entopeduncular nucleus and ventral telencephalon send projections to fish HB, exact targets remain unclear (purple). mPFC: medial prefrontal cortex; VTA: ventral tegmental area; SNc: substantia nigra, pars compacta; RMTg: rostromedial tegmental nucleus; Dl: pars lateralis of the dorsal telencephalic area. Modified from Aizawa et al. (26) and Mizumori and Baker (28).