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. 2020 Apr 28;31(4):107583. doi: 10.1016/j.celrep.2020.107583

Figure 5.

Figure 5

Assembly of Vaccine Design Adapted BG505-ST-710 into Peptidiscs

(A) Examples of BG505-ST-710 peptidiscs with and without the addition of MPER-targeting Fabs as determined from negative-stain EM 2D class averages.

(B) Antigenic profiling of BG505-ST-710 peptidiscs compared to equivalent soluble Env (BG505-ST-664) by lectin capture-based biolayer interferometry. The top graph shows binding signals of the indicated Fabs after normalization to the respective PGT121 signal. Exemplary traces of the indicated Fabs are shown below.

(C) Antigenicity comparison of AMC011FL in detergent micelles and lipid nanodiscs with protein A-IgG capture mode.

See also Table S1.