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Contacting Regions between Env and MPER-Targeting Antibody 10E8 Mapped from the Cryo-EM Reconstruction of AMC011FL Nanodisc in Complex with the Fab
| Env | 10E8 Fab |
|---|---|
| Ectodomain | |
| gp41 α8-helix (residues 619-622) | CDRH1 (25-33) |
| gp120 residues (499-500) | HC FR3 (73-77) |
| gp120 N terminus | |
| Ectodomain-MPER | |
| HR2 | CDRH2 (52-56) |
| MPER peptide | CDRH3 (99-100H) |
| Lipids/bilayer | CDRL1 (26-30) |
| LC FR3 (67-69) | |
