Fig. 2.

Remodeling and loss of key genes of the MHC class I and II pathways among 14 species of Syngnathiformes. Species are arranged according to their phylogeny (SI Appendix, Fig. S1). The copy numbers of the most important genes of the MHC I pathway (MHC I, B2M, CD8a, CD8b and TAP1, TAP2, TAP2T) and MHC II pathway (MHC IIα, MHC IIβ, AICDA [AID], AIRE, CD4, CD74, CIITA, RAG1, RAG2) are displayed. Superscript “1” specifies large fragmented genomes; superscript “2” specifies previously published genomes. White boxes indicate loss of genes and half green boxes indicate loss of exons.