Fig. 3.

Domain-level alignment of three genes (CD74, AIRE, CIITA) critical for the MHC class II pathway with lost or divergent exons in Hippocampus and Syngnathus compared to other vertebrate sequences. For each exon, sequence divergence to other teleosts (yellow), human (34), or sequence conservation other teleosts (green), human (blue) are shown. Exon loss is indicated in white and sequence conservation between Hippocampus and Syngnathus but divergence to other teleosts/humans in gray. Orange triangles indicate the number of sites under positive selection. An ansterisk (*) indicates yellow exon 6b and 7 of CD74 also diverge between Syngnathus and Hippocampus.