Supplementary Table 1.
Plasma Lipid Mediator Profiles
Survivors |
Non-survivors |
|||||||
---|---|---|---|---|---|---|---|---|
Day 1 |
Day 5 |
Day 1 |
Day 5 |
|||||
Average | SEM | Average | SEM | Average | SEM | Average | SEM | |
DHA bioactive metabolome (pg/mL) | ||||||||
RvD1 | 0.30 | 0.16 | 0.46 | 0.29 | 2.34 | 1.57 | 1.04 | 0.34 |
RvD2 | 0.68 | 0.20 | 2.98 | 2.16 | 0.63 | 0.29 | 13.46 | 7.22 |
RvD3 | 0.17 | 0.10 | 0.18 | 0.15 | 0.42 | 0.08 | 0.21 | 0.07 |
RvD4 | 0.98 | 0.55 | 1.31 | 0.63 | 3.81 | 1.34 | 2.24 | 0.94 |
RvD5 | 1.21 | 0.83 | 1.44 | 0.52 | 0.57 | 0.25 | 1.77 | 0.59 |
RvD6 | 0.72 | 0.40 | 0.73 | 0.25 | 0.54 | 0.17 | 0.40 | 0.22 |
17R-RvD1 | 1.00 | 0.81 | 0.11 | 0.06 | 0.21 | 0.17 | 0.38 | 0.15 |
17R-RvD3 | 0.12 | 0.05 | 0.10 | 0.09 | 0.08 | 0.06 | 0.26 | 0.20 |
PD1 | 0.84 | 0.46 | 4.74 | 3.98 | 0.80 | 0.52 | 3.39 | 2.05 |
10S,17SdiHDHA | 5.94 | 4.21 | 9.35 | 8.39 | 7.75 | 4.49 | 3.60 | 1.78 |
17R-PD1 | 0.51 | 0.25 | 0.89 | 0.48 | 0.27 | 0.19 | 0.20 | 0.07 |
PCTR1 | 1.24 | 1.38 | 1.46 | 1.21 | 1.66 | 1.85 | 0.93 | 0.99 |
PCTR2 | 1.22 | 0.89 | 123.44 | 117.81 | 0.00 | 0.00 | 25.12 | 26.75 |
PCTR3 | 16.51 | 18.45 | 2.55 | 2.75 | 0.00 | 0.00 | 43.99 | 30.11 |
MaR1 | 0.00 | 0.00 | 1.44 | 1.01 | 0.00 | 0.00 | 3.81 | 1.65 |
MaR2 | 0.79 | 0.51 | 0.29 | 0.14 | 0.31 | 0.22 | 0.78 | 0.37 |
7S,14S-diHDHA | 8.74 | 6.73 | 9.99 | 4.36 | 7.45 | 6.34 | 15.89 | 7.31 |
22-OH-MaR1 | 0.00 | 0.00 | 1.12 | 1.10 | 0.91 | 0.65 | 4.73 | 2.21 |
4S,14S-diHDHA | 0.59 | 0.42 | 0.36 | 0.15 | 0.13 | 0.08 | 0.14 | 0.08 |
MCTR1 | 19.54 | 21.85 | 0.82 | 0.89 | 9.04 | 10.11 | 0.00 | 0.00 |
MCTR2 | 2.26 | 2.53 | 49.75 | 53.73 | 0.00 | 0.00 | 0.22 | 0.23 |
MCTR3 | 46.72 | 50.54 | 22.74 | 21.50 | 16.75 | 13.01 | 1.46 | 1.56 |
n-3 DPA bioactive metabolome (pg/mL) | ||||||||
RvT1 | 0.38 | 0.38 | 0.67 | 0.41 | 0.35 | 0.25 | 1.55 | 0.88 |
RvT2 | 0.12 | 0.07 | 0.41 | 0.32 | 1.48 | 1.40 | 1.40 | 1.05 |
RvT3 | 0.48 | 0.14 | 5.06 | 5.14 | 0.73 | 0.31 | 1.00 | 0.55 |
RvT4 | 0.44 | 0.24 | 0.42 | 0.21 | 0.60 | 0.40 | 0.74 | 0.39 |
RvD1n3 DPA | 0.77 | 0.28 | 0.48 | 0.09 | 0.47 | 0.19 | 1.81 | 0.61 |
RvD2n3 DPA | 0.38 | 0.27 | 1.37 | 0.87 | 1.09 | 0.50 | 3.32 | 2.15 |
RvD5n3 DPA | 1.05 | 0.55 | 1.49 | 0.79 | 1.18 | 0.88 | 1.21 | 0.96 |
PD1n3 DPA | 0.81 | 0.47 | 0.37 | 0.17 | 1.22 | 0.23 | 0.30 | 0.22 |
10S,17S-diHDPA | 0.60 | 0.30 | 0.12 | 0.13 | 0.62 | 0.43 | 0.48 | 0.47 |
PD2n3 DPA | 0.26 | 0.20 | 0.41 | 0.18 | 0.39 | 0.35 | 0.06 | 0.06 |
MaR1n3 DPA | 0.36 | 0.40 | 1.06 | 0.50 | 0.20 | 0.22 | 1.08 | 0.71 |
7S,14S-diHDPA | 0.37 | 0.26 | 0.19 | 0.20 | 1.34 | 1.14 | 0.89 | 0.49 |
MaR2n3 DPA | 5.58 | 1.92 | 5.36 | 1.90 | 6.62 | 3.72 | 8.67 | 5.95 |
EPA bioactive metabolome (pg/mL) | ||||||||
RvE1 | 0.71 | 0.59 | 2.62 | 1.17 | 0.46 | 0.45 | 2.51 | 1.31 |
RvE2 | 0.46 | 0.36 | 0.59 | 0.28 | 0.00 | 0.00 | 3.36 | 3.30 |
RvE3 | 2.00 | 0.68 | 1.98 | 0.59 | 0.00 | 0.00 | 1.73 | 1.49 |
AA bioactive metabolome (pg/mL) | ||||||||
LXA4 | 0.20 | 0.12 | 1.51 | 1.41 | 0.22 | 0.17 | 0.35 | 0.22 |
LXB4 | 56.89 | 33.64 | 28.43 | 9.18 | 49.68 | 26.23 | 32.28 | 14.62 |
5S,15S-diHETE | 0.67 | 0.75 | 0.70 | 0.55 | 0.94 | 0.51 | 0.46 | 0.24 |
15-epi-LXA4 | 0.76 | 0.46 | 2.25 | 1.24 | 4.03 | 2.48 | 4.85 | 2.73 |
15-epi-LXB4 | 0.00 | 0.00 | 5.99 | 3.66 | 0.93 | 0.80 | 1.39 | 1.04 |
LTB4 | 59.61 | 39.43 | 19.08 | 10.53 | 13.32 | 7.91 | 7.38 | 2.79 |
5S,12S-diHETE | 0.57 | 0.64 | 0.85 | 0.44 | 2.51 | 1.95 | 3.91 | 2.56 |
20-OH-LTB4 | 39.32 | 24.93 | 41.82 | 25.07 | 7.22 | 4.76 | 19.70 | 15.52 |
LTC4 | 104.49 | 42.32 | 245.07 | 58.23 | 140.27 | 60.57 | 380.26 | 212.29 |
LTD4 | 2.28 | 1.08 | 2.57 | 2.48 | 2.46 | 2.32 | 5.54 | 3.88 |
LTE4 | 99.42 | 75.69 | 44.22 | 22.49 | 17.65 | 5.42 | 15.99 | 2.57 |
PGD2 | 47.06 | 32.13 | 13.55 | 5.12 | 26.30 | 15.98 | 10.14 | 4.67 |
PGE2 | 158.05 | 127.58 | 49.01 | 23.36 | 62.15 | 60.14 | 11.75 | 2.49 |
PGF2a | 92.10 | 66.27 | 32.92 | 16.63 | 129.55 | 135.36 | 15.65 | 4.06 |
TXB2 | 760.53 | 562.20 | 280.12 | 158.57 | 441.14 | 291.99 | 761.01 | 632.45 |
AA, arachidonic acid; DHA, docosahexaenoic acid; DPA, docosapentaenoic acid; EPA, eicosapentaenoic acid; SEM, standard error of the mean.