Supplementary Table 2.
Plasma Cytokine and Chemokine Levels
| Plasma analyte | Survivors |
Non-survivors |
HV |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Day 1 |
Day 5 |
Day 1 |
Day 5 |
|||||||
| pg/mL | SD | pg/mL | SD | pg/mL | SD | pg/mL | SD | pg/mL | SD | |
| CCL2 | 378.4 | 174.6 | 323.7 | 131.1 | 266.1 | 192.9 | 319.4 | 194.3 | 159.4 | 51.9 |
| CCL3 | 41.8 | 17.8 | 31.6 | 46.4 | 38.9 | 16.4 | 27.4 | 12.9 | 13.9 | 2.8 |
| CCL4 | 159 | 114.1 | 135.1 | 100.8 | 99.5 | 19.8 | 92.1 | 27.6 | 34.9 | 5.8 |
| CCL17 | 80.3 | 12.2 | 126 | 34.2 | 157.3 | 30.5 | 86.9 | 17.1 | 50.3 | 21.3 |
| CCL22 | 378.9 | 74 | 764.5 | 164.6 | 932 | 136.8 | 408 | 62.4 | 838.7 | 200.3 |
| Eotaxin | 914.8 | 480.8 | 885.1 | 315.4 | 842.2 | 459.4 | 1047.8 | 429.6 | 647.4 | 126.4 |
| Eotaxin-3 | 138.5 | 66.1 | 150.7 | 59.3 | 117.4 | 43.2 | 142.7 | 60.7 | 647.4 | 126.4 |
| GM-CSF | 0.18 | 0.04 | 0.17 | 0.04 | 0.18 | 0.04 | 0.10 | 0.03 | 0.06 | 0.03 |
| IFN-γ | 8.54 | 2.53 | 9.14 | 2.18 | 3.29 | 1.05 | 6.16 | 2.24 | 1.78 | 0.99 |
| IL1α | 2.05 | 3.21 | 2.67 | 1.82 | 4.85 | 5.2 | 4.52 | 3.70 | n/a | n/a |
| IL1β | 0.59 | 0.14 | 1.7 | 0.42 | 0.41 | 0.12 | 1.34 | 0.95 | n/a | n/a |
| IL2 | 0.62 | 0.27 | 0.89 | 0.35 | 0.36 | 0.23 | 0.58 | 0.33 | 1.17 | 1.06 |
| IL4 | 0.082 | 0.02 | 0.19 | 0.05 | 0.065 | 0.02 | 0.056 | 0.01 | 0.03 | 0.01 |
| IL5 | 0.73 | 0.5 | 1.17 | 1 | 0.67 | 0.26 | 1.04 | 0.74 | 0.56 | 0.20 |
| IL6 | 17.5 | 7.16 | 20.68 | 5.08 | 26.3 | 9.66 | 20.94 | 9.5 | 0.13 | 0.04 |
| IL7 | 6.43 | 1.49 | 4.95 | 0.84 | 5.20 | 1.07 | 5.32 | 0.91 | 2.93 | 0.63 |
| IL8 | 265.4 | 35 | 359.3 | 202.4 | 261.1 | 68.7 | 156.8 | 34.9 | 3.6 | 1.14 |
| IL10 | 1.06 | 0.24 | 1.03 | 0.34 | 1.13 | 0.28 | 1.63 | 0.43 | 0.13 | 0.07 |
| IL12p70 | 0.45 | 0.37 | 0.58 | 0.60 | 0.29 | 0.07 | 0.58 | 0.60 | 0.18 | 0.07 |
| IL13 | 2.12 | 1.53 | 2.82 | 2.13 | 1.59 | 0.85 | 2.19 | 2.85 | 0.72 | 0.39 |
| IL15 | 7.28 | 1.7 | 5.73 | 1.9 | 7.36 | 4.13 | 6.0 | 1.58 | 2.68 | 0.51 |
| IL16 | 358.9 | 218.6 | 341.3 | 250.2 | 472.3 | 543.05 | 511.2 | 344.1 | 142.8 | 35.17 |
| IL17 | 5.97 | 1.86 | 6.01 | 1.78 | 3.26 | 0.39 | 2.59 | 0.28 | 2.18 | 0.74 |
| IL23 | 99.23 | 124.6 | 90.1 | 61.54 | 94.68 | 79.16 | 64.9 | 54.9 | 105.7 | 52.3 |
| IP-10 | 1104.1 | 1040.9 | 1085.2 | 568.5 | 729.3 | 499.3 | 1085.2 | 568.5 | 220.4 | 63.3 |
| MCP-4 | 334.5 | 81.8 | 443.4 | 51 | 344.3 | 45.6 | 636.6 | 80.9 | 243.4 | 96.8 |
| TNF-α | 4.45 | 0.83 | 4.05 | 0.97 | 5.52 | 1.44 | 4.33 | 0.78 | 1.26 | 0.11 |
| TNF-β | 0.53 | 0.17 | 0.42 | 0.10 | 0.52 | 0.14 | 0.48 | 0.11 | 0.29 | 0.06 |
| VEGF | 130.9 | 163.3 | 125.7 | 157.1 | 32.71 | 20 | 103.4 | 172.8 | 12.38 | 2.04 |
GM-CSF, granulocyte-macrophage colony-stimulating factor; IFN, interferon; IL, interleukin; IP-10, interferon gamma–induced protein 10; MCP, monocyte chemoattractant protein-4; SD, standard deviation; TNF, tumor necrosis factor; VEGF, vascular endothelial growth factor.