Table 3.

Correlations between clinical severity and systemic inflammatory parameters

Variables	Apoptotic neutrophils		Apoptotic monocytes		Apoptotic lymphocytes		Total apoptotic leukocytes		Nuclear DNA		VCAN-1		P-selectin		L-selectin
	R	p	R	p	R	p	R	p	R	p	R	p	R	p	R	p
Disease duration	0.056	0.594	0.017	0.870	− 0.059	0.572	0.066	0.533	0.362	< 0.001*	− 0.014	0.895	0.119	0.248	0.078	0.448
Treatment duration	0.057	0.587	0.091	0.387	0.262	0.011	0.206	0.048	− 0.068	0.513	0.245	0.016	− 0.257	0.011	− 0.167	0.103
Current daily dosage	0.097	0.353	− 0.005	0.965	− 0.062	0.557	0.124	0.238	0.154	0.133	0.205	0.046	0.004	0.967	0.042	0.685
UPDRS I	0.157	0.138	− 0.111	0.297	− 0.132	0.214	0.089	0.404	0.220	0.033	0.009	0.930	0.061	0.562	− 0.086	0.411
UPDRS II	0.203	0.053	0.022	0.837	− 0.041	0.699	0.201	0.056	0.333	0.001*	0.115	0.269	0.198	0.056	0.060	0.568
UPDRS III	0.313	0.002*	− 0.027	0.799	− 0.084	0.431	0.227	0.031	0.270	0.009	0.171	0.098	0.083	0.428	0.065	0.532
UPDRS 176	0.284	0.006*	− 0.022	0.832	− 0.081	0.445	0.219	0.037	0.302	0.003*	0.148	0.153	0.121	0.244	0.052	0.619
Modified H&Y stage	0.229	0.029	− 0.067	0.530	− 0.138	0.194	0.156	0.140	0.257	0.012	0.192	0.064	− 0.052	0.617	0.029	0.779
S&E scale	− 0.248	0.018	0.054	0.611	0.090	0.394	− 0.156	0.140	− 0.255	0.013	− 0.105	0.312	0.008	0.943	0.040	0.700

Partial correlation analysis adjusted for age and gender was performed to correlate the inflammatory parameters with the clinical severity

*p < 0.05, threshold for statistical significance with a Bonferroni correction accounting for multiple region of interest comparisons