Figure 1.

Schematic representation of fatty acid cellular uptake in the kidneys. FA transport across the plasma membrane occurs mainly by protein-mediated mechanisms or receptor-mediated endocytosis. In the cells, FAs bind to different FABPs with respect to the subcellular localization and have multiple functions in energy generation and storage, membrane synthesis, and activation of nuclear transcription factors like PPAR/RXR. Abbreviations: FATP: fatty acid transport protein; FABP: fatty acid-binding protein; FAO: fatty acid oxidation; PPAR: peroxisome proliferator-activated receptor; RXR: retinoid X receptor.