Jackevicius 2001.

Methods	Study design: ITS
Participants	Physicians Clinical speciality: internal medicine, cardiology, not specified Level of training: fully trained Setting/country: hospital/inpatient/Canada
Interventions	The PEM consisted of the 4S, published in 1994, which demonstrated that lipid lowering with simvastatin resulted in a clear and substantial decrease in total mortality and in fewer CHD events and less cardiovascular mortality when used in patients with CHD (history of angina or myocardial infarction) who also had high LDL‐cholesterol levels
Outcomes	1 process outcome: prescription for statin (all statins)
Notes	‐
Risk of bias
Bias	Authors' judgement	Support for judgement
Intervention independent of other changes ‐ ITS	High risk	Quote, pg. 187: "it is impossible to separate the effects of the publication of 4S, the subsequent continuing education efforts, and the effects of marketing by the pharmaceutical industry. Therefore, the results of this study show the effects of the combined efforts among many different parties to promote appropriate medication prescribing with lipid‐lowering therapy in patients after AMI"
Shape of Intervention effect pre‐specified ‐ ITS	Unclear risk	Quote, pg. 183: "the use of statins in patients after AMI represents a proven innovation that is not complex to use, that has been endorsed by professional societies and practice guidelines, and that has been aggressively marketed by drug manufacturers. Analysis of the use of statins may provide us with information on the extent to which it is possible to change prescribing behaviour in a large population when strong clinical evidence and practice guidelines are combined with aggressive marketing"
Intervention unlikely to affect data collection ‐ ITS	Low risk	The intervention (4S) did not affect either the source or method of data collection
Blinding of outcome assessors (detection bias) ‐ ITS All outcomes	Low risk	The outcome was objective.
Incomplete outcome data (attrition bias) ‐ ITS All outcomes	Low risk	Quote, pg. 184: "all Ontario residents 65 years or older are covered under a comprehensive drug benefit plan. Each time a prescription is filled, a claim is submitted to the provincial government that contains the patient health insurance number and a unique drug identifier. The Ontario Myocardial Infarction Database provides data on all elderly patients treated for AMI in any Ontario hospital and records any prescriptions filled after hospital discharge"
Selective reporting (reporting bias) ‐ ITS	Low risk	All relevant outcomes in the methods section were reported in results section
Other bias ‐ ITS	Low risk	There was no evidence of other risks of bias