Table 2.

Summary of ANCOVA results for ROI analysis demonstrating differences in cortical NDI, with and without controlling for cortical thickness

	MCI vs. control				AD vs. control
	NDI (uncorrected)		NDI (corrected for CT)		NDI (uncorrected)		NDI (corrected for CT)
ROI	β	P FDR	β	P FDR	β	P FDR	β	P FDR
Frontal	−4.7E − 3	0.095	−4.4E − 3	0.125	−6.9E − 3	0.016	−5.3E − 3	0.095
Temporal	−7.7E − 3	4.1E − 3	−6.7E − 3	0.019	−1.3E − 2	2.4E − 7	−1.1E − 3	2.5E − 4
Parietal	−6.5E − 3	0.032	−5.9E − 3	0.037	−1.1E − 2	7.2E − 5	−7.9E − 3	8.6E − 3
Precuneus	−5.5E − 3	0.061	−5.3E − 3	0.093	−1.0E − 2	5.4E − 4	−8.6E − 3	8.6E − 3
Ant. cingulate	−4.1E − 3	0.095	−4.2E − 3	0.115	−4.0E − 3	0.106	−4.1E − 3	0.095
Post. cingulate	−6.0E − 3	0.032	−5.9E − 3	0.037	−1.3E − 2	4.8E − 6	−1.2E − 2	4.3E − 5
Entorhinal	−8.4E − 3	0.061	−5.4E − 3	0.181	−1.5E − 2	6.7E − 4	−8.3E−3	0.077
Parahippocampal	−3.4E − 3	0.258	-3.0E − 3	0.330	−7.5E − 3	0.022	−6.6E − 3	0.070

ANCOVA models tested the effect of diagnosis on NDI, controlling for age, sex, and with and without cortical thickness; bold indicates P_FDR < 0.05; CT = cortical thickness; AD = Alzheimer’s disease dementia group.