Table 1.

Changes in key known tear inflammatory mediators in soft contact lens wear and contact lens related situations in human’s studies.

Tear Protein	Healthy SCL Wear	Multipurpose Solution	Contact lens induced CIEs
IL-1β	↓[112], ↑[124]	–	–
IL-6	↑[2,108,116]; ↓[124] ↑Trend[120]	↑[125,126]	↑[117,127]
IL-8	↑[2,116], =[112,124] ↑Trend[120]	↑[126]	↑[117,127]
IL-10	–	–	↑[127]
IL-12	↓[112]	–	–
IL-17A	–	↑[125]	–
TNF- α	=[112]	↑[125]	–
MMP-9	↑[128] ↑Trend[120]	–	–
NGF	=[123]	–	–
Substance P	=[14]	–	–
CGRP	=[14]	–	–

NGF: nerve growth factor, CGRP: calcitonin gene related peptide; SCL: soft contact lens; CIEs: corneal infiltrative events; ↑: increase; ↓: decrease; ^___: not reported; =: No significant changes.