Fig. 6.

NSDHL expression correlates with poor prognosis in breast cancer. a Kaplan-Meier plots of recurrent free survival based on the combination of NSDHL expression in breast cancer patient; b Schematic overview of the regulatory mechanisms affected by NSDHL knockdown in breast tumor growth and metastasis. Knockdown of NSDHL may result in an accumulation of meiosis-activating sterol (MAS), which influences EGFR degradation, and dysregulated EGFR-mediated signals suppresses SREBP-1 expression, leading to suppression of lipogenesis and cholesterol biosynthesis