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. Author manuscript; available in PMC: 2021 Apr 2.
Published in final edited form as: Mol Cell. 2020 Feb 12;78(1):152–167.e11. doi: 10.1016/j.molcel.2020.01.027

Figure 7: Harnessing the Exd–shape mutant to decipher complex-specific biological functions.

Figure 7:

Contact-based promoter-peak type assignment reveals distinct functions for Exd-Antp target genes. Significance of enrichment for specific Gene Ontology (GO) categories is shown either based on all upregulated genes associated with any Exd peak (X-axis) or only those associated with a specific Exd complex. Dotted lines indicate the p-value threshold at which significance is met after accounting for multiple hypothesis testing. Bottom panel shows whether the same GO categories are significantly enriched among genes both upregulated in the Exd–shape mutant and specifically expressed in the central nervous system (CNS, dark blue) or wing disc (khaki) based on a transcriptome analysis comparing wild-type larval CNS and wing. “missed by all” highlights GO categories that were not identified when the entire set of Exd peaks was analyzed.