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Important molecules involved in creatine metabolism including CEST detectable protons (blue) and MRS detectable protons (red). Creatine has 3 equivalent labile protons, phosphocreatine has 1 equivalent labile proton (1 nonequivalent) and creatinine has 2 equivalent labile protons. (Lower panel) representative axial MRI of calf muscle and kidneys, two locations for detecting these metabolites.
