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. 2020 Apr 24;26:e920665-1–e920665-9. doi: 10.12659/MSM.920665

Figure 2.

Figure 2

PCDH8 inhibited the invasion and migration of KYSE-150 cells. (A, B) Invasion and migration abilities of KYSE-150 cells transfected with pcDNA-PCDH8 or NC were measured by Transwell assays. PCDH8 overexpression significantly decreased the migratory and invasive ability of ESCC cells. (C) PCDH8 overexpression upregulated the levels of E-cadherin and p-AKT but downregulated the levels of N-cadherin and vimentin. (D) ELISA was performed to determine the protein level of VEGFA secreted by KYSE-150 cell. PCDH8 overexpression remarkably inhibited VEGFA expression. (E) Tube formation was significantly decreased when PCDH8 was overexpressed. Representative images of HUVEC tube formation were captured at 6 hours after cell seeding. * P<0.05, ** P<0.01.