Table 4.

Measures of Performance for Case Definitions^*

Definition Number	Area Under the ROC Curve (95% Confidence Interval)	Sensitivity (%)	Specificity (%)	PPV (%)
1	0.90 (0.88, 0.92)	96.5	83.8	91.5
2	0.91 (0.89, 0.93)	90.7	91.3	95.0
3	0.87 (0.85, 0.88)	85.1	93.7	96.1
4	0.87 (0.85, 0.89)	79	95.2	96.8
5	0.77 (0.74, 0.79)	99.2	54.1	79.7
6	0.92 (0.90, 0.94)	93.7	89.5	94.2
7	0.91 (0.89, 0.93)	86.3	95.2	97.0
8	0.87 (0.85, 0.89)	77.5	95.5	96.9
9	0.83 (0.81, 0.85)	69.1	97.6	98.1
10	0.80 (0.77, 0.82)	92.1	67	83.5
11	0.85 (0.83, 0.87)	75.2	94.9	96.4
12	0.77 (0.75, 0.79)	55.7	97.9	98.0
13	0.69 (0.67, 0.71)	40	98.8	98.4
14	0.77 (0.74, 0.79)	69.8	83.5	88.5
15	0.70 (0.68, 0.73)	42.6	98.2	97.7
16	0.63 (0.62, 0.65)	27.8	99.1	98.2
17	0.59 (0.57, 0.60)	18	99.4	98.2
18	0.75 (0.73, 0.77)	51.7	98.5	98.4
19	0.64 (0.62, 0.66)	28.3	99.4	98.8
20	0.58 (0.57, 0.60)	16.9	99.7	99.0
21	0.54 (0.53, 0.55)	8.4	99.7	98.1
22	0.74 (0.72, 0.77)	52.6	96.1	96.1
23	0.64 (0.63, 0.66)	29.8	99.1	98.4
24	0.59 (0.57, 0.60)	17.5	99.7	99.1
25	0.55 (0.54, 0.56)	9.6	**	**
26	0.72 (0.70, 0.74)	44.3	99.4	99.3
27	0.61 (0.60, 0.63)	22.8	99.7	99.3
28	0.56 (0.55, 0.57)	12.6	99.7	98.7
29	0.53 (0.52, 0.54)	6.3	**	**
30	0.83 (0.81, 0.85)	67.9	97.6	98.1
31	0.77 (0.75, 0.80)	71.7	82.9	88.4
32	0.81 (0.79, 0.84)	80	82.3	89.1
33	0.83 (0.80, 0.85)	84.5	81.4	89.2
34	0.86 (0.83, 0.88)	92.1	79.3	89.0
35	0.76 (0.73, 0.79)	99.2	52.6	79.2
36	0.76 (0.73, 0.78)	99.3	52	79.0
37	0.91 (0.89, 0.92)	90.2	90.4	94.5

^*Children continuously enrolled in Michigan Medicaid in 2010 with either confirmed SCD or not SCD as identified by Newborn Screening records

^**Zero false positives cases