Table 1.
Ketamine pharmacokinetic parameters during the continuous high-dose infusion compared to published values.
| Parameter | Observed | ICU Patientsa | Healthyb |
|---|---|---|---|
| Caverage,ss (ng/mL) | 1018.69 | - | - |
| Vd (L/kg) | 14.18 | 16 | 2.18 |
| CL (L/hour/kg) | 1.96 | 2.16 | 0.89 |
| ke (hr−1) | 0.14 | 0.31 | 0.38 |
| t1/2 (hours) | 5 | 4.98 | 3.27 |
ICU = Intensive care unit, Caverage,ss = average concentration at steady-state, Vd = volume of distribution, CL = total plasma clearance, ke = elimination rate constant, t1/2 = half-life.
a
Mean values in 12 intensive care patients following a 2 mg/kg intravenous bolus and 2 mg/kg/hour infusion over 2 hours.10
b
Mean values in 10 healthy adult subjects following a 9–10 mg/kg/hour short infusion.9