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. 2020 May 1;34(9-10):701–714. doi: 10.1101/gad.335281.119

Figure 1.

Figure 1.

dERR is required for maximal life span, starvation resistance, and adult locomotor activity. (A) The genomic locus for the dERR conditional allele is depicted with the two FRT insertion sites (green boxes) and the 3XPax3-dsRed marker gene (red). The two isoforms for dERR are shown (ERR-RA and ERR-RB), including protein-coding sequences (blue boxes) and UTRs (gray boxes). (B,D) Life span was scored for controls (blue) and dERR mutants (red) on a normal diet (B) or following water-only starvation initiated on day 6 of adulthood (D). Median life spans: controls: normal diet, 77 d (n = 76); water, 5 d (n = 141); dERR mutants: normal diet, 47 d (n = 140); water, 4 d (n = 144). (C) Locomotor activity was measured as a fraction of total vial height achieved for controls (blue) and dERR mutants (red) using the RING assay. Animals were fed a normal diet and assayed on day 6 of adulthood. n = 8 independent samples with 10 animals per sample. (***) P ≤ 0.001; (**) P ≤ 0.01.