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. 2020 May 1;34(9-10):701–714. doi: 10.1101/gad.335281.119

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© 2020 Beebe et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 8. — A model for dERR function in adult metabolism. dERR directly induces genes in glycolysis and the pentose phosphate pathway (PPP), highlighted with gray boxes. The end product of glycolysis, pyruvate, enters the TCA cycle to undergo oxidative phosphorylation for ATP production. Relatively little pyruvate is converted to lactate due to low levels of Ldh expression in adults. Cytoplasmic citrate, derived from the TCA cycle, is converted into the critical precursor for lipogenesis, acetyl CoA, by ATP citrate lyase (ATPCL), which is up-regulated by dERR in adults. NADPH from the PPP provides the reducing power for efficient lipogenesis, supporting the synthesis of fatty acids, the precursor for stored triglycerides. Mitochondrial activity is independently up-regulated in adults by the dHNF4 nuclear receptor.