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. 2020 May 1;34(9-10):621–636. doi: 10.1101/gad.332577.119

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© 2020 Mona et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — Reduced PTF1A levels affect specification of Gad1 and Glyt2 (Slc6a5) inhibitory neurons. (A–C) ISH shows a decrease in Glyt2 (A) and Gad1 (B), but no significant change in VGlut2 (Slc17a6) (C) neurons in Ptf1a enhancer mutants with the scratch phenotype (AR-DNT1, AR1, and AR4) at P30 compared with WT. (A′–C′) Quantification reports the number of marker⁺ cells per hemisection from superficial (gray in diagram) or deep dorsal spinal cord regions for the markers shown in A–C, respectively. Each data point represents a biological replicate (N), error bars indicate SEM. Student's t-test was used to determine significant differences relative to WT, P-values are as indicated. (*) P < 0.05; (**) P < 0.01; (****) P < 0.0001. Scale bar, 100 µm. See also Supplemental Fig. S4.