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. Author manuscript; available in PMC: 2020 May 4.
Published in final edited form as: Neuron. 2019 Jun 25;103(4):719–733.e7. doi: 10.1016/j.neuron.2019.05.040

Figure 7. Model of Neuronal Ensemble Dynamics Supporting Improved Trajectory Replay.

Figure 7.

(A) (Top) Cartoon model of hippocampal ensemble activity before (Pre-Run sleep, one frame) and after (Post-Run sleep, one frame) a de novo spatial experience (Run, cell assembly sequence) proposed to underlie episodic-like spatial memory formation. Colored circles depict different significant cell assemblies (multi-neuronal millisecond-timescale coactivation patterns) across sleep and run as detected based on their activity during Run. Letters depict significantly active cell assemblies; variable size of circles during sleep depicts activation strength. Vertical dash lines within sleep frame mark periods of significant activation of each assembly identified based on their activity during Post-Run sleep. (Bottom) Spikes of individual neurons are depicted by short vertical lines color coded according to the cell assembly they belong to during Run.

(B) Schematic depicting confirmed (observed) and unconfirmed (not observed) phenomena proposed to underlie representation of de novo spatial experience by compressed neuronal ensemble dynamics during sleep.