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Schematic representation of human skin and epidermolysis bullosa (EB). (A) Epidermal layers (left) and the epidermal–dermal junction (middle) are designated. The right panel denotes the hemidesmosome and its components, in relation to EB simplex (EBS), junctional EB (JEB), and dystrophic EB (DEB). (B) Proteins involved in the pathogenesis of EBS, JEB, and DEB and site of blister formation.
