. Author manuscript; available in PMC: 2020 Oct 1.

Published in final edited form as: J Thromb Haemost. 2019 Jul 23;17(10):1683–1693. doi: 10.1111/jth.14543

Table 2.

Toll-like receptor deficiency impacts plasma procoagulants and IL-6 at 24 hours after sham or CLP surgery.

Strain	Intervention	TF	Fibrinogen	PAI-1	Il-6

		(pg/mL)	(mg/mL)	(pg/mL)	(pg/mL)
WT	Sham	22.9±0.99	3.08±0.13	47.6±26.3	58.6±14.1
	CLP	112.6±20.7^***	3.53±0.31	39,001±10828^**	142,890±24442^****



TLR7^−/−	Sham	23.4±0	2.91±0.12	28.1±12.29	118±4.25
	CLP	24.7±5.7^Δ	4.41±0.62^*	23,571±7563^**	12,249±3391^**^/ΔΔΔ

TLR2^−/−	Sham	23.4±0	3.05±0.18	9.38±0	15.6±0
	CLP	39.3±5.97^*	4.04±0.23^**	52,027±12927^**	4,734±3239^ΔΔ

MyD88^−/−	Sham	23.4±25	2.22±0.27	9.38±0	51.3±16.6
	CLP	25±4.52^Δ	4.54±0.39^***	27,206±8099^*	6,814±2009^*^/ΔΔΔ

Trif^−/−	Sham	23.4±0	2.72±0.12	9.38±0	16.7±5.95
	CLP	68.7±35.3	5.88±0.45^***	46,040±16549^*	64,686±32823



TLR3^−/−	Sham	23.4±0	2.93±0.15	9.38±0	7.69±3.24
	CLP	92.8±33.8	2.36±0.47	26,114±6338^**	39,778±16656

TLR4^−/−	Sham	23.4±0	3.26±0.21	9.38±0	66.4±23.2
	CLP	113.9±30.9^*	2.12±0.60	44,391±16723^*	109,463±34771^**

* or ^# represents significant difference between sham and CLP mice within the same strain.

^Δ

represents significant difference between WT CLP and TLR^−/− CLP mice.

P = 0.05

P < 0.05

^**

P < 0.01

^***

P < 0.001

^****

P < 0.0001

WT (Sham= 18–23, CLP= 26–33), TLR3^−/− (Sham= 5–6, CLP= 5–6), TLR4^−/− (Sham= 4–5, CLP= 4–5), TLR2^−/− (Sham= 6, CLP= 5–6), TLR7^−/− (Sham= 7–11, CLP= 7–12), MyD88^−/− (Sham= 7–8, CLP= 8–12), and Trif^−/− (Sham= 4, CLP= 6)

CLP = cecal ligation and puncture, MCF = maximum clot firmness, TLR = Toll-like receptor.