1. Methods of HRQoL analysis and results.

Author	Test of statistical significance applied	Difference between treatment arms	Clinical difference addressed	Presentation of results	Missing data documented	Exploration of missing data
Allal 2000	YES	NO	NO	YES	NO	NO
Allal 2005	YES	NO	NO	YES	YES	NO
Arndt 2006	YES	NO	YES	YES	NO	NO
Bloemen 2009	YES	YES	NO	YES	NO	NO
CamilleriBrennan2002	YES	YES	NO	YES	NO	NO
Campos‐Lobato 2011	YES	NO	YES	YES, SUMMARY	NO	NO
Celasin 2011	YES	NO	NO	YES	NO	NO
Engel 2003	YES	YES	NO	YES	YES	NO
Fischer 2011	YES	YES	NO	YES	NO	NO
Fucini 2008	YES	YES	NO	YES	NO	NO
Gosselink 2005	YES	YES	NO	YES	NO	NO
Grumann 2001	YES	NO	NO	YES	NO	NO
Grundmann 1989	YES	YES	NO	YES	NO	NO
Guren 2005	YES	YES	YES	YES	YES	(YES)
Hamashima 2002	YES	NO	NO	YES	NO	NO
Harisi 2004	YES	NO	NO	YES	NO	NO
Jess 2002	YES	NO	NO	YES	NO	NO
Kasparek 2011	YES	YES	YES	YES	YES	(YES)
Krouse 2009	YES	YES	YES	YES	NO	NO
Kuzu 2002	YES	YES	NO	YES	NO	NO
Marquis 1992	YES	YES	NO	YES	NO	NO
Peng 2011	YES	YES	NO	YES	NO	NO
Perez Lara 2004	YES	YES	NO	YES	NO	NO
Pucciarelli 2008	YES	YES	NO	YES	NO	NO
Rauch 2004	YES	NO	NO	YES	YES	NO
Ross 2006	YES	YES	NO	YES	NO	NO
Schmidt 2005	YES	YES	NO	YES	NO	NO
Schmidt 2010	YES	YES	NO	YES	NO	NO
Sideris 2005	YES	YES	NO	YES	NO	NO
Smidt‐Gagen 2010	YES	NO	YES	YES	NO	NO
Thong 2010	YES	YES	YES	YES	NO	NO
Varpe 2011	YES	NO	NO	YES	NO	NO
Vironen 2006	YES	NO	NO	YES	NO	NO
Yau 2009	YES	YES	NO	YES	NO	NO
Yoo 2005	YES	NO	NO	YES	YES	NO