Figure 2. Lactate-induced PD-L1 in MEER cells does not depend on GPR81 signaling.

(A) Relative transcript levels of GPR81 in MEER and MOE LXSN cells. (B) cAMP levels measured by a cAMP-GloMax assay in PBS or 10 mM lactate-treated MEER cells. (C) Relative transcript levels of PD-L1 in MEER cells treated with either 10 mM lactate or PBS and 100 nM PTX (black) or DMSO (gray). ^** p < 0.01, ^**** p < 0.0001.