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. 2020 Apr 27;11:315. doi: 10.3389/fpsyt.2020.00315

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Copyright © 2020 Navarrete, García-Gutiérrez, Jurado-Barba, Rubio, Gasparyan, Austrich-Olivares and Manzanares

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Main findings regarding the therapeutic potential of the functional manipulation of the endocannabinoid system (ECS) components by pharmacological and genetic approaches in anxiety, depression, schizophrenia, and post-traumatic stress disorder (PTSD). CB1r, cannabinoid receptor 1; CB2r, cannabinoid receptor 2; AEA, anandamide; 2-AG, 2-arachidonoylglycerol; FAAH, fatty acid amide hydrolase; MAGL, monoacylglycerol lipase; 5-HT, serotonin; NA, noradrenaline; DA, dopamine; AcH: acetylcholine; GABA, gamma-aminobutyric acid; Glu, glutamate; HPA axis, Hypothalamus–Pituitary–Adrenal axis; *, chronic treatment.