Table 5.
Degradation (%) of remdesivir and GS-441524 in different conditions: aliquots of QCs maintained in different conditions and ‘stressed’
| After 24 h at |
Freeze and thaw |
Storage at −80°C, months |
Thermal inactivationa |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| QC standard | RT | 37°C | 4°C | −20°C | 2°C | 3°C | 1 | 2 | 4 | 5 | 7 | standard | standard + 24 h RT |
| Remdesivir | |||||||||||||
| high | 93 | 99 | 17 | 0 | 6 | 6 | 0 | 4 | 0 | 0 | 0 | 9 | 26 |
| medium | 95 | 100 | 17 | 0 | 10 | 4 | 8 | 0 | 0 | 7 | 0 | 5 | 24 |
| low | 100 | 100 | 22 | 2 | 5 | 8 | 16 | 2 | 0 | 0 | 0 | 4 | 27 |
| GS-441524 | |||||||||||||
| high | 0 | 0 | 1 | 0 | 1 | 0 | NA | NA | 0 | ongoing | ongoing | 4 | 0 |
| medium | 5 | 5 | 1 | 0 | 8 | 0 | NA | NA | 0 | ongoing | ongoing | 0 | 1 |
| low | 0 | 0 | 0 | 0 | 4 | 0 | NA | NA | 0 | ongoing | ongoing | 0 | 0 |
NA, not available.
a
Standard thermal inactivation was 58°C for 38 min.