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. 2020 Apr 26;2020(4):CD013595. doi: 10.1002/14651858.CD013595
Stage Criteria Cell mass
I All of the following:
  • haemoglobin value > 10 g/dL

  • normal serum calcium value of < 12 mg/dL

  • normal bone structure or one solitary bone lesion only on radiography

  • low M‐component production rates

  • IgG < 5 g/dL

  • IgA < 3 g/dL

  • urine light chain M‐component on electrophoresis of < 4 g/24 h

< 0.6 x 1012 cells/mm2
II One or more of the following:
  • haemoglobin value of ≤ 10g/dL and ≥ 8.5g/dL

  • normal serum calcium value of ≤ 12mg/dL

  • normal bone structure or one solitary bone lesion only on radiography

  • M‐component production rates

  • IgG ≥ 5 g/dL and ≤ 7 g/dL

  • IgA ≥ 3 g/dL and ≤ 5 g/dL

  • urine light chain M‐component on electrophoresis of ≥ 4 g/24 h and ≤ 12 g/24h

≥ 0.6 x 1012 cells/mm2 and ≤ 1.2 x 1012 cells/mm2
III One or more of the following:
  • haemoglobin value of < 8.5 g/dL

  • serum calcium value of > 12 mg/dL

  • advanced lytic bone lesions

  • high M‐component production rates

  • IgG > 7 g/dL

  • IgA > 5 g/dL

  • urine light chain M‐component on electrophoresis of > 12 g/24 h

> 1.2 x 1012 cells/mm2