| 1.1 FEV1 post‐intervention [% predicted] |
4 |
|
Std. Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 1.1.1 Up to one week |
2 |
78 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.03 [‐0.48, 0.41] |
| 1.1.2 Over one week and up to two weeks |
1 |
30 |
Std. Mean Difference (IV, Random, 95% CI) |
0.12 [‐0.60, 0.84] |
| 1.1.3 Over two weeks and up to one month |
1 |
44 |
Std. Mean Difference (IV, Random, 95% CI) |
0.49 [‐0.11, 1.09] |
| 1.2 FEV1 change from baseline [% predicted] |
5 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 1.2.1 Over one week and up to two weeks |
1 |
22 |
Mean Difference (IV, Fixed, 95% CI) |
9.37 [‐6.16, 24.90] |
| 1.2.2 Over two weeks and up to one month |
1 |
12 |
Mean Difference (IV, Fixed, 95% CI) |
‐4.08 [‐12.82, 4.66] |
| 1.2.3 At one year |
3 |
162 |
Mean Difference (IV, Fixed, 95% CI) |
1.54 [‐1.97, 5.06] |
| 1.3 FEF25-75 post intervention [% predicted] |
4 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 1.3.1 Up to one week |
2 |
78 |
Mean Difference (IV, Fixed, 95% CI) |
0.09 [‐9.33, 9.52] |
| 1.3.2 Over one week and up to two weeks |
1 |
30 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.00 [‐27.84, 25.84] |
| 1.3.3 Over two weeks and up to one month |
1 |
44 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.00 [‐3.95, 1.95] |
| 1.4 FEF25-75 change from baseline [% predicted] |
5 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 1.4.1 Over one week and up to two weeks |
1 |
22 |
Mean Difference (IV, Fixed, 95% CI) |
15.26 [‐10.12, 40.64] |
| 1.4.2 Over two weeks and up to one month |
1 |
12 |
Mean Difference (IV, Fixed, 95% CI) |
‐20.07 [‐45.00, 4.86] |
| 1.4.3 At one year |
3 |
162 |
Mean Difference (IV, Fixed, 95% CI) |
0.13 [‐4.46, 4.72] |
| 1.5 FVC post intervention [% predicted] |
4 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 1.5.1 Up to one week |
2 |
78 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.66 [‐8.71, 7.40] |
| 1.5.2 Over one week and up to two weeks |
1 |
30 |
Mean Difference (IV, Fixed, 95% CI) |
3.00 [‐10.60, 16.60] |
| 1.5.3 Over two weeks and up to one month |
1 |
44 |
Mean Difference (IV, Fixed, 95% CI) |
2.00 [‐0.09, 4.09] |
| 1.6 FVC change from baseline [% predicted] |
4 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 1.6.1 Over one week and up to two weeks |
1 |
22 |
Mean Difference (IV, Random, 95% CI) |
5.40 [‐9.21, 20.01] |
| 1.6.2 At one year |
3 |
162 |
Mean Difference (IV, Random, 95% CI) |
0.25 [‐6.14, 6.65] |
| 1.7 Sputum volume [ml] |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 1.7.1 Up to 1 week |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 1.8 Sputum weight [g] |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 1.8.1 Over one week and up to two weeks |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 1.9 Quality of life indices |
2 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 1.9.1 Quality of well being score |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 1.9.2 CRQ Disease specific interviewer administered questionnaire |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 1.9.3 CFQ: physical domain |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 1.9.4 CFQ: emotional domain |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 1.9.5 CFQ: treatment burden domain |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 1.9.6 CFQ: respiratory domain |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 1.9.7 CFQ: digestion/weight domain |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 1.10 Number of hospitalizations |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 1.10.1 At one year |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 1.11 Pulmonary exacerbations (at 1 year) |
1 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 1.11.1 Total number of patient requiring antibiotics for exacerbations |
1 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 1.11.2 Number of patients requiring IV antibiotics for exacerbations |
1 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 1.12 Exercise performance % change from baseline |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 1.12.1 Over one week and up to two weeks |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 1.13 Participant satisfaction |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 1.13.1 Over one week and up to two weeks |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
