| 3.1 FEV1 post intervention [% predicted] |
4 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 3.1.1 Up to one week |
2 |
52 |
Mean Difference (IV, Random, 95% CI) |
4.24 [‐7.96, 16.44] |
| 3.1.2 Over one week and up to two weeks |
1 |
20 |
Mean Difference (IV, Random, 95% CI) |
18.00 [‐5.54, 41.54] |
| 3.1.3 Over two weeks and up to one month |
1 |
28 |
Mean Difference (IV, Random, 95% CI) |
2.00 [‐2.83, 6.83] |
| 3.1.4 Over one month and up to six months |
1 |
16 |
Mean Difference (IV, Random, 95% CI) |
10.00 [‐3.72, 23.72] |
| 3.2 FEV1 change from baseline [% predicted] |
2 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 3.2.1 Up to one week |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 3.2.2 Over one week and up to two weeks |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 3.2.3 Over two weeks and up to one month |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 3.3 FEF25-75 post intervention [% predicted] |
3 |
|
Std. Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 3.3.1 Up to one week |
2 |
52 |
Std. Mean Difference (IV, Random, 95% CI) |
0.24 [‐0.35, 0.83] |
| 3.3.2 Over one week and up to two weeks |
1 |
20 |
Std. Mean Difference (IV, Random, 95% CI) |
0.65 [‐0.27, 1.58] |
| 3.3.3 Over one month and up to six months |
1 |
16 |
Std. Mean Difference (IV, Random, 95% CI) |
0.29 [‐0.70, 1.28] |
| 3.4 FEF25-75 change from baseline [% predicted] |
2 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 3.4.1 Up to one week |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 3.4.2 Over one week and up to two weeks |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 3.4.3 Over two weeks and up to one month |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 3.5 FVC [% predicted] |
4 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 3.5.1 Up to one week |
2 |
52 |
Mean Difference (IV, Fixed, 95% CI) |
2.60 [‐8.63, 13.84] |
| 3.5.2 Over one week and up to two weeks |
1 |
20 |
Mean Difference (IV, Fixed, 95% CI) |
13.00 [‐10.54, 36.54] |
| 3.5.3 Over two weeks and up to one month |
1 |
28 |
Mean Difference (IV, Fixed, 95% CI) |
3.00 [‐0.78, 6.78] |
| 3.5.4 Over one month and up to six months |
1 |
16 |
Mean Difference (IV, Fixed, 95% CI) |
11.00 [‐2.86, 24.86] |
| 3.6 Residual volume [% change from baseline] |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 3.6.1 Up to one week |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 3.6.2 Over one week and up to two weeks |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 3.7 Sputum weight (dry) [g] |
6 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 3.7.1 Up to one week |
5 |
228 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.03 [‐0.13, 0.06] |
| 3.7.2 Over one week and up to two weeks |
1 |
24 |
Mean Difference (IV, Fixed, 95% CI) |
0.13 [‐0.16, 0.42] |
| 3.7.3 Over two weeks and up to one month |
1 |
28 |
Mean Difference (IV, Fixed, 95% CI) |
0.10 [‐0.35, 0.55] |
| 3.8 Sputum weight (wet) [g] |
6 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 3.8.1 Up to one week |
5 |
228 |
Mean Difference (IV, Fixed, 95% CI) |
1.11 [‐0.60, 2.83] |
| 3.8.2 Over one week and up to two weeks |
1 |
24 |
Mean Difference (IV, Fixed, 95% CI) |
4.04 [‐2.69, 10.77] |
| 3.8.3 Over two weeks and up to one month |
1 |
28 |
Mean Difference (IV, Fixed, 95% CI) |
1.00 [‐2.56, 4.56] |
| 3.9 Six minute walking distance [metres] |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 3.9.1 Over one week and up to two weeks |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 3.10 Oxygen saturation (SaO2 ) [% change from baseline] |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 3.10.1 Up to one week |
1 |
50 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.20 [‐1.51, 1.11] |
| 3.10.2 Over one week and up to two weeks |
1 |
50 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.10 [‐1.51, 1.31] |
| 3.11 Days of hospitalization |
3 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 3.11.1 Over one week and up to two weeks |
2 |
70 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.01 [‐1.99, 1.97] |
| 3.11.2 Over one month and up to six months |
1 |
16 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.70 [‐6.95, 3.55] |
| 3.12 Patient satisfaction / overall preference (short term) |
2 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 3.12.1 up to one week |
2 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 3.13 Patient satisfaction / overall preference (long term) |
2 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 3.13.1 Effectiveness |
2 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 3.13.2 Convenience |
2 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 3.13.3 Discomfort |
2 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 3.13.4 Overall satisfaction |
2 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 3.13.5 Mean score |
2 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
