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. 2020 Apr 30;2020(4):CD006842. doi: 10.1002/14651858.CD006842.pub5

Khan 2014.

Study characteristics
Methods RCT.
Parallel design.
Location: single centre in Russia.
Duration: 10 'procedures' (not clear how many procedures per day).
Participants 30 children aged 5 ‐ 17 years.
Interventions HFCWO versus control (control not mentioned so alternative ACT unknown, assumed that 15 participants were randomised to each treatment group).
Outcomes FEV1, FVC, exercise tolerance, sputum volume and SpO₂
But as we are unaware of the alternative "control" ACT we cannot include the data in the meta‐analysis.
Notes Only abstract in English, therefore translation required but even following translation the paper had limited quality and limited information as to the actual interventions and their frequency.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Stratified randomisation declared, not described.
Allocation concealment (selection bias) Unclear risk Not mentioned.
Blinding (performance bias and detection bias)
All outcomes Unclear risk Not mentioned.
Incomplete outcome data (attrition bias)
All outcomes Low risk No drop outs. All 30 data sets included in their analysis
Selective reporting (reporting bias) Unclear risk No objective data on sputum volume, although it was stated there was an improvement following the intervention.
Other bias Unclear risk Not clear as abstract only in English and no clear evidence of excluded bias in translated paper.