Phillips 2004.

Study characteristics
Methods	RCT. Cross‐over design (no washout period). Location: single centre in UK. Duration: 2 days.
Participants	10 participants (7 males, 3 females). Median (range) age: 14 (9 ‐ 16) years. CF diagnosed via sweat chloride testing or genetic testing. Participants admitted to the Brompton Hospital with an acute exacerbation as defined by conventional criteria and were adept at self‐treatment of ACBT.
Interventions	ABCT versus HFCWO. 2 supervised treatments of either ACBT or HFCWO on 2 successive dates for 20 min.
Outcomes	FVC, FEV1 (measured immediately before, immediately after and 10 min after each treatment), wet sputum weight (measured over 24‐hour period, during treatment and 15 minutes after treatment), participant preference (measured at the end of the study).
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Described as randomised but generation of sequence not identified.
Allocation concealment (selection bias)	Low risk	Via sealed envelope.
Blinding (performance bias and detection bias) All outcomes	Low risk	Individual who collected sputum weight was blinded to therapy type.
Incomplete outcome data (attrition bias) All outcomes	Low risk	Data set complete, no drop outs identified.
Selective reporting (reporting bias)	Unclear risk	Not possible to compare study protocol with final paper.
Other bias	High risk	Paper identifies potential weakness of the study in that is short term and concludes that potentially a longer term study may have demonstrated improved adherence.