TABLE 1.

Differentially expressed characterized genes comparing grade 3 and normal valves with high stringency criteria (FDR Q-value < 0.1).

Gene symbol	Description	Fold change	Gene symbol	Description	Fold change
NT5E	5-nucleotidase, ecto (CD73)	–2.93	ACYP2	Acylphosphatase 2, muscle type	1.63
TANC2	Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	–1.72	BNC2	Basonuclin 2	1.82
CCDC65	Coiled-coil domain containing 65	–1.69	NOV	Nephroblastoma overexpressed	1.87
ENPP2	Ectonucleotide pyrophosphatase/phosphodiesterase 2	–1.64	CDKN2B	Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	1.94
LOC 102152842	Zinc finger protein 512-like	–1.51	PLCXD3	Phosphatidylinositol-specific phospholipase C, X domain containing 3	2.98
LOC 480571	Septin-4	1.51	CDKN2A	Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	5.34
UBTD1	Ubiquitin domain containing 1	1.55	LRRN1	Leucine rich repeat neuronal 1	6.1
FAM174A	Family with sequence similarity 174, member A	1.58	CDKN2A	Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	7.79

Genes appearing more than once were represented by more than one probe set on the array.