TABLE 2.
Differentially characterized expressed genes between grade 4 and normal valves with high stringency criteria (FDR Q-value < 0.1).
| Gene symbol | Description | Fold change | Gene symbol | Description | Fold change |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | –3.68 | KCNQ5 | Potassium channel, voltage gated KQT-like subfamily Q, member 5 | –1.71 |
| CILP | Cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | –3.64 | SLC1A3 | Solute carrier family 1 member 3 | –1.67 |
| NT5E | 5-nucleotidase, ecto (CD73) | –2.99 | PDGFRL | Platelet-derived growth factor receptor-like | –1.65 |
| TMEFF2 | Transmembrane protein with EGF-like and two follistatin-like domains 2 | –2.73 | SNTB1 | Syntrophin, beta 1 | –1.63 |
| ADCYAP1 | Adenylate cyclase activating polypeptide 1 (pituitary) | –2.65 | CACNA2D1 | Calcium channel, voltage-dependent, alpha 2/delta subunit 1 | –1.6 |
| WIF1 | WNT inhibitory factor 1 | –2.6 | MPP6 | Membrane protein, palmitoylated 6 | –1.59 |
| MIR218-1 | MicroRNA mir-218-1 | –2.6 | SCARA5 | Scavenger receptor class A, member 5 | –1.59 |
| KCNQ5 | Potassium channel, voltage gated KQT-like subfamily Q, member 5 | –2.07 | TYW3 | tRNA-yW synthesizing protein 3 homolog | –1.58 |
| LRP1B | Low density lipoprotein receptor-related protein 1B | –2.01 | MOB3B | MOB kinase activator 3B | –1.52 |
| ALDH1A1 | Aldehyde dehydrogenase 1 family, member A1 | –2 | LOC 489911 | Zinc finger protein 688-like, 785 and 764 | –1.52 |
| IGF2BP2 | Insulin-like growth factor 2 mRNA binding protein 2 | –2 | ERBB4 | Erb-b2 receptor tyrosine kinase 4 | –1.51 |
| TMEFF2 | Transmembrane protein with EGF-like and two follistatin-like domains 2 | –1.95 | SRSF2 | Serine/arginine-rich splicing factor 2 | –1.51 |
| CRISPLD2 | Cysteine-rich secretory protein LCCL domain containing 2 | –1.93 | FAM174A | Family with sequence similarity 174, member A | 1.51 |
| AFF2 | AF4/FMR2 family, member 2 | –1.9 | CDR2 | Cerebellar degeneration-related protein 2, 62 kDa | 1.51 |
| PTGFR | Prostaglandin F receptor (FP) | –1.86 | RAI14 | Retinoic acid induced 14 | 1.55 |
| OVGP1 | Oviductal glycoprotein 1, 120 kDa | –1.85 | CYR61 | Cysteine-rich, angiogenic inducer, 61 | 1.58 |
| SCIN | Scinderin | –1.84 | |||
| ARGLU1 | Arginine and glutamate rich 1 | –1.84 | LOC 479476 | Arachidonate 12-lipoxygenase, 12S-type | 1.59 |
| SNTB1 | Syntrophin, beta 1 | –1.73 | CDKN1A | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 1.62 |
| NOV | Nephroblastoma overexpressed | 1.65 | BMP6 | Bone morphogenetic protein 6 | 2.19 |
| NME1 | Non-metastatic cells 1, | 1.65 | KCNMB1 | Potassium channel subfamily M regulatory beta subunit 1 | 2.25 |
| COL4A1 | Collagen, type IV, alpha 1 | 1.66 | ANGPT1 | Angiopoietin 1 | 2.33 |
| LOC 100856638 | Uridine phosphorylase 1 | 1.68 | NTRK3 | Neurotrophic tyrosine kinase, receptor, type 3 | 2.4 |
| ADAM22 | ADAM metallopeptidase domain 22 | 1.7 | NLGN4X | Neuroligin 4, X-linked | 2.51 |
| BNC2 | Basonuclin 2 | 1.72 | LRRC3B | Leucine rich repeat containing 3B | 2.73 |
| LBH | Limb bud and heart development | 1.77 | TPM2 | Tropomyosin 2 (beta) | 2.83 |
| GAP43 | Growth associated protein 43 | 1.78 | HTR2B | 5-hydroxytryptamine (serotonin) receptor 2B, | 3.11 |
| ARNTL2 | Aryl hydrocarbon receptor nuclear translocator-like 2 | 1.79 | CDKN2A | Cyclin-dependent kinase inhibitor 2A, p16 | 3.23 |
| ATP8B1 | ATPase, amino-phospholipid | 1.82 | CCL13 | Chemokine (C-C motif) ligand 13 | 3.82 |
| GPER1 | G protein-coupled estrogen receptor 1 | 1.87 | LRRN1 | Leucine rich repeat neuronal 1 | 3.89 |
| ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | 1.88 | SERPINE1 | Serpin peptidase inhibitor, clade E member 1 | 4.34 |
| MFSD2A | Major facilitator superfamily domain containing 2A | 1.9 | CDKN2A | Cyclin-dependent kinase inhibitor 2A. P16 | 5.07 |
| CLEC3A | C-type lectin domain family 3, member A | 1.95 |
Genes appearing more than once were represented by more than one probe set on the array.