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. 2020 May 4;15(5):e0230950. doi: 10.1371/journal.pone.0230950

Fig 1. Pathway analysis and modeling procedure.

Fig 1

(A) Three phases of pathway analysis: (1) input the high-throughput biological data (HTBD) variants from the VCF file; (2) perform the algorithm-based analysis and GVB scoring; (3) visualize the pathway and annotate with the GVB scores. (B) Development procedure for default pathways and personalized pathways. VCF: Variant Call Format; GVB: Gene-wise Variant Burden; GPML: Graphical Pathway Markup Language; SVG: Scalable Vector Graphics; PNG: Portable Network Graphics; HTML: Hypertext Markup Language; PD: Pharmacodynamics.