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. 2020 May 4;15(5):e0232233. doi: 10.1371/journal.pone.0232233

Table 1. Significant KEGG pathways detected by analyzing every differentially expressed gene (DEG) in Alzheimer’s disease model mice.

Aβ group compared with Sham group Aβ+YW group compared with Aβ group The number of DEGs KEGG pathway (Benjamini-Hochberg FDR<0.05)
Upregulation
281 genes
Downregulation 153 • Chemokine signaling pathway
• Retrograde endocannabinoid
signaling
• Nicotine Addiction
• GABAergic synapse
• Morphine addiction
• Cytokine-cytokine receptor
interaction
• MAPK signaling pathway
Not Change
21634 genes
- - -
Downregulation
291 genes
Upregulation 179 • Ribosome
• Cocaine addiction
• Dopaminergic synapse
Total
22206 genes
- Total
332
-