Table 1. Significant KEGG pathways detected by analyzing every differentially expressed gene (DEG) in Alzheimer’s disease model mice.
Aβ group compared with Sham group | Aβ+YW group compared with Aβ group | The number of DEGs | KEGG pathway (Benjamini-Hochberg FDR<0.05) |
---|---|---|---|
Upregulation 281 genes |
Downregulation | 153 | • Chemokine signaling pathway • Retrograde endocannabinoid signaling • Nicotine Addiction • GABAergic synapse • Morphine addiction • Cytokine-cytokine receptor interaction • MAPK signaling pathway |
Not Change 21634 genes |
- | - | - |
Downregulation 291 genes |
Upregulation | 179 | • Ribosome • Cocaine addiction • Dopaminergic synapse |
Total 22206 genes |
- | Total 332 |
- |