Table 1. Significant KEGG pathways detected by analyzing every differentially expressed gene (DEG) in Alzheimer’s disease model mice.

Aβ group compared with Sham group	Aβ+YW group compared with Aβ group	The number of DEGs	KEGG pathway (Benjamini-Hochberg FDR<0.05)
Upregulation 281 genes	Downregulation	153	• Chemokine signaling pathway • Retrograde endocannabinoid signaling • Nicotine Addiction • GABAergic synapse • Morphine addiction • Cytokine-cytokine receptor interaction • MAPK signaling pathway
Not Change 21634 genes	-	-	-
Downregulation 291 genes	Upregulation	179	• Ribosome • Cocaine addiction • Dopaminergic synapse
Total 22206 genes	-	Total 332	-