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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Neurobiol Dis. 2019 Jul 22;132:104539. doi: 10.1016/j.nbd.2019.104539

Figure 9. TAF1 gene editing leads to a decrease in frequency of spontaneous excitatory post synaptic current in cerebellar Purkinje cells.

Figure 9.

Photomicrograph of cerebellar slice preparation with a progressive zoom with the rightmost panel showing positioning of the recording electrode to this region (A). Representative recording traces of cells from the indicated groups (B). The cumulative probability of amplitude (C) and inter-event interval (E). Summary of amplitudes (D) and frequencies (F) of sEPSCs for the indicated groups are shown. Data are shown as mean ± S.E.M., n = 12 Purkinje cells from at least 2 animals per experimental condition. *p<0.05 versus; naïve, #p<0.05 versus gRNA-control (ANOVA followed by Tukey’s test). The experiments were conducted in an investigator blinded manner.