Table 2.
Results From Primary Meta-Analysis
| Endpoint | Efficacy Subgroup* | Within Subgroups | Between Subgroups (Heterogeneity) | ||||
|---|---|---|---|---|---|---|---|
|
|
|
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| No. of Studies | Pooled Hedges’ g (95% CI) | P | I2 | Q (df) | P | ||
| Total score | Non-efficacious | 6 | 0.23 (−0.04, 0.50) | 0.092 | 0% | ||
| Efficacious | 10 | 0.67 (0.51, 0.83) | <0.001 | 74.1% | 7.45 (1) | 0.006 | |
| Bowel symptoms | Non-efficacious | 2 | 0.16 (−0.22, 0.53) | 0.404 | 0% | ||
| Efficacious | 3 | 0.58 (0.47, 0.70) | <0.001 | 0% | 4.51 (1) | 0.034 | |
| Systemic symptoms | Non-efficacious | 2 | 0.07 (−0.30, 0.45) | 0.701 | 0% | ||
| Efficacious | 3 | 0.50 (0.38, 0.61) | <0.001 | 0% | 4.50 (1) | 0.034 | |
| Emotional function | Non-efficacious | 2 | 0.10 (−0.27, 0.47) | 0.600 | 0% | ||
| Efficacious | 3 | 0.49 (0.37, 0.60) | <0.001 | 0% | 3.82 (1) | 0.051 | |
| Social function | Non-efficacious | 2 | 0.05 (−0.32, 0.42) | 0.793 | 0% | ||
| Efficacious | 3 | 0.55 (0.44, 0.67) | <0.001 | 0% | 6.41 (1) | 0.011 | |
*
Efficacious treatments are those which achieved their primary endpoint; non-efficacious treatments are thosefor the which primary endpoint was not met.