Table 4. Pooled measures for associations between the UCP2 -866G/A and Ins/Del polymorphisms and susceptibility to DKD.
| Inheritance model | n studies | n controls | n cases | I2 (%) | Pooled OR (95% CI) |
|---|---|---|---|---|---|
| UCP2 -866 G/A | |||||
| Allele contrastb | 4 | 717 | 648 | 46.0 | 1.03 (0.88-1.21) |
| Additiveb | 4 | 390 | 351 | 0.0 | 1.04 (0.75-1.45) |
| Recessiveb | 4 | 717 | 648 | 0.0 | 1.05 (0.78-1.42) |
| Dominanta | 4 | 717 | 648 | 53.2 | 1.04 (0.74-1.45) |
| UCP2 Ins/Del | |||||
| Allele contrastb | 4 | 719 | 641 | 0.0 | 0.96 (0.81-1.14) |
| Additiveb | 4 | 444 | 413 | 0.0 | 1.08 (0.71-1.63) |
| Recessiveb | 4 | 719 | 641 | 13.3 | 1.11 (0.74-1.65) |
| Dominantb | 5 | 937 | 857 | 0.0 | 0.89 (0.74-1.08) |
a If significant heterogeneity was detected (I2 > 50%), the DerSimonian and Laird random effect model (REM) was used to calculated OR (95% CI); b if heterogeneity was not significant, the fixed effect model (FEM) was used for this calculation. DKD: diabetic kidney disease.