TABLE 2: Comparison of serum and kidney levels of oxidative stress and inflammation indicator parameters.
| Parameters | Group 1 | Group 2 | Group 3 | Group 4 |
|---|---|---|---|---|
| Control | Sepsis | Sepsis + Cefazolin | Sepsis + Cefazolin + Etanercept | |
| (n = 7) | (n = 7) | (n = 7) | (n = 7) | |
| Serum | ||||
| CRP (pmol/L) | 18.43 ± 6.37 | 46.50 ± 6.12a | 26.40 ± 5.30b | 20.07 ± 5.27b |
| TNF-α (ng/L) | 41.74 ± 13.73 | 149.78 ± 25.02a | 109.14 ± 8.15a,b | 45.54 ± 3.7b,c |
| TREM (pg/mL) | 93.77 ± 11.55 | 172.03 ± 19.69a | 144.12 ± 23.03a,b | 97.78 ± 14.60b,c |
| MDA (nmol/mL) | 1.49 ± 0.54 | 3.07 ± 0.71a | 2.33 ± 0.72 | 1.50 ± 0.41b |
| Kidney tissue | ||||
| CRP (pmol/L) | 23.52 ± 10.29 | 32.88 ± 19.35 | 27.26 ± 11.97 | 21.47 ± 5.41 |
| TNF-α (ng/L) | 33.88 ± 10.07 | 93.07 ± 41.95a | 78.5 ± 23.84a | 44.67 ± 13.76b |
| TREM (pg/mL) | 54.77± 14.96 | 146.89 ± 76a | 116.35 ± 18.62 | 59.66 ± 25.07b |
| MDA (nmol/mL) | 0.66 ± 0.36 | 1.39 ± 0.63a | 1.18 ± 0.43 | 1.01 ± 0.06 |
CRP: C-reactive protein, TNF-α: tumor necrosis factor alpha, TREM: triggering receptor expressed on myeloid cells, MDA: malondialdehyde. ap < 0.05 in comparison with control group. bp < 0.05 in comparison with sepsis group. cp < 0.05 in comparison with sepsis + cefazolin group