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The role of modeling and simulation within each step of antimalarial research and development. Modeling and simulation translate experimental data to predictions and inform the next step in development. Abbreviations: NOD, nonobese diabetic; PBPK, physiologically based pharmacokinetic; PD, pharmacodynamics; PK, pharmacokinetics; QSAR, quantitative structure-activity relationship; SCID, severe combined immunodeficiency.
