Table 1.
Patient characteristics and clinical data.
| Variables | Population study (n=12) |
|---|---|
| Age (yr) | 62 (56–66) |
| BMI (kg m−2) | 29.5 (29.3–32.4) |
| Male/female (n) | 10/2 |
| SOFA score before ECMO | 11 (10–14) |
| Ventilator settings before ECMO | |
| Tidal volume (ml kg−1) | 6.1 (5.8–6.2) |
| Respiratory rate (bpm) | 30 (30–31) |
| PEEP (cm H2O) | 14 (12–15) |
| Plateau pressure (cm H2O) | 28 (26–28) |
| Driving pressure (cm H20) | 14 (12–15) |
| Compliance (ml cm H2O−1) | 31 (23–32) |
| Laboratory data before ECMO | |
| pH | 7.3 (7.22–7.37) |
| PaO2 (kPa) | 9.3 (8.1–10.5) |
| PaO2/FiO2 (kPa) | 9.3 (8–10.5) |
| PaCO2 (kPa) | 8.1 (7.2–8.5) |
| Lactate (mmol L−1) | 2.5 (2–3) |
| White blood count (mm−3) | 10.900 (9525–11875) |
| Lymphocyte count ×106 L−1 | 616 (397–900) |
| Platelet count ×109 L−1 | 240 (151–329) |
| C-reactive protein (mg L−1) | 280 (214–345) |
| Procalcitonin (μg L−1) | 2.6 (1.7–7) |
| aPTT | 1.4 (1.3–1.5) |
| PT (%) | 60 (52–70) |
| Anti-Xa UFH assay (IU ml−1) | 0 (0–0.2) |
| Fibrinogen (g L−1) | 7 (6–9) |
| D-Dimer (μg ml−1) | 8.3 (4.7–24) |
| Fibrinogen degradation product (μg ml−1) | 51 (3–76) |
| Sepsis-induced coagulopathy score | 3.5 (2–4) |
| Laboratory data during ECMO therapy on Day 2 | |
| Platelet count ×109 L−1 | 200 (124–327) |
| aPTT | 1.6 (1.4–2.8) |
| PT (%) | 70 (63–80) |
| Anti-Xa UFH assay (IU ml−1) | 0.3 (0.1–0.5) |
| Fibrinogen (g L−1) | 7.5 (4.9–9.0) |
| Duration from ICU admission to ECMO (days) | 6.5 (4.2–8.0) |
| Duration from intubation to ECMO (days) | 4 (1.5–7.5) |
| Prone positioning before ECMO | 12 (100) |
|
2 (1.2–3) |
| Nitric oxide treatment | 8 (83) |
| ECMO initiation | |
| In ECMO centre | 2 (17) |
| Out of ECMO centre | 10 (83) |
| DVT before ECMO | |
| Jugular | 1 (8) |
| Femoral | 5 (41) |
| Anticoagulation therapy before ECMO | 6 (50) |
| Thrombotic complications | 4 (33) |
| Cannula thrombosis | 2 (17) |
| Oxygenator thrombosis | 1 (8) |
| Massive PE | 1 (8) |
| Death related to thrombotic complication | 2 (17) |
| Outcome | |
| Still on ECMO | 8 (66) |
| ECMOvv converted to ECMOva | 0 |
| Weaned from ECMO and still in hospital | 2 (16) |
|
1 (8) |
| Discharge from ICU | 0 |
| Discharge from hospital | 0 |
Data are presented as median (interquartile range) or n (%).
aPTT, activated partial thromboplastin time; BMI, body mass index; ECMOva, veno-arterial extracorporeal membrane oxygenation; ECMOvv, veno-venous extracorporeal membrane oxygenation; MV, mechanical ventilation; PE, pulmonary embolism; PT, prothrombin time; UFH, unfractionated heparin.