. 2020 May 4;2(6):e358–e367. doi: 10.1016/S2665-9913(20)30096-5

Table 3.

Reported cases of cytokine storm syndrome (including sHLH/MAS) treated with intravenous anakinra

	Patient details	Underlying diagnosis	IV anakinra	Other acute management	Maintenance	Length of follow-up (months)
Chou et al (2010)⁶¹	36-year-old female	MDS	Details not specified	Corticosteroids 1 mg/kg per day	Anakinra (assumed SC); prednisolone 40 mg/day	2
Nigrovic et al (2011);⁶² Record et al (2011)⁶³	4-year-old female	sJIA, diagnosed at 8 months of age	11·2 mg/kg per day (5·6 mg/kg twice a day); duration unspecified	Corticosteroids 1·1 mg/kg per day; MTX; 0·8 mg/kg per week	Anakinra 0·9 mg/kg per day (assumed SC); steroids 0·9 mg/kg per day; MTX 0·7 mg/kg per week; abatacept IV 0·3mg/kg per 3 weeks	24
Loh et al (2012)⁶⁴	20-year-old male	AOSD	200 mg once daily for 6 days	Methylprednisolone; IV hydrocortisone; CSA 100 mg twice daily	Anakinra 100 mg SC; once-daily; MTX 10 mg once-weekly	Unknown
Acker et al (2015)⁶⁵	22-month-old male	Septic arthritis	Details not specified	Prednisolone oral	Anakinra (assumed SC)	24
Kemps et al (2017)⁶⁶	71-year-old male	CMV and AAV	400 mg every 3 days for 10 days	Not specified	Not specified	Unknown
Eloseily et al (2020)⁴¹	19-year-old female	SLE	48 mg/kg per day for 3 days	Not specified	Not applicable	Died
Eloseily et al (2020)⁴¹	8-year-old male	HHV-6	8–48 mg/kg per day for 1 month	Etoposide; dexamethasone; solumedrol; CSA 4 mg/kg per day	Not applicable	Died
Eloseily et al (2020)⁴¹	16-year-old female	Gastroparesis and CMV	4–48 mg/kg per day for 3 months	Methylprednisolone; CSA 4 mg/kg per day; abatacept; tocilizumab	Not applicable	Died

MDS=myelodysplastic syndrome. SC=subcutaneous. sJIA=systemic juvenile idiopathic arthritis. MTX=methotrexate. AOSD=adult-onset Still's disease. IV=intravenous. CSA=ciclosporin. CMV=cytomegalovirus. AAV=ANCA-associated vasculitis. SLE=systemic lupus erythematosus. HHV-6=human herpes virus-6.